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Prof. Dr. Isabelle Mansuy - Molekulares Bewusstseinmore information

Project leader	Project title
Mansuy	Nuclear functions of PP1 in memory-associated neuronal processes
	The role of calcineurin in associative memory
	Memory traces in the brain
	Analysis of phosphatase pathways in the brain by proteomics methods
	Immediate early genes and their role in learning and memory
	Study of the impact of early trauma on behavior across generations
	Neural mechanisms of early life stress
	Study of calcineurin- and PP1-dependent pathways involved in learning and memory
	Genome-wide expression and methylation analysis in mice with enhanced learning and memory
	Determining the Ensemble of Histone PTMs Associated with Memory Formation and Cognitive Decline, and Regulated by PP1 using Mass Spectrometry
	The role of calcineurin and PP1 in memory with aging and environmental enrichment
	RNA/DNA samples quality control
	Applying multiple reaction monitoring to monitor changes in the proteasome during learning
	RNA/DNA samples quality control, enrichment of small
	The role of small-RNAs in learning and memory
	The role of DNA hydroxymethylation in learning and memory
	Genome-wide analysis of histone PTMs in fear memory by ChIP followed by massively parallel sequencing
	Genome-wide analysis of PP1-dependent chromatin remodeling in cognitive deficits by SAGE-Seq and proteomics
	Sequential ChIP-Seq of histone PTM combinations to define the validity of the histone code in learning and memory
	fMRI of the mouse serotonergic system

Project leader	Project title
Mansuy	Study of calcineurin- and PP1-dependent pathways involved in learning and memory
	Proteomic and in silico analyses of combinatorial post-translational modifications on histone proteins in the adult mouse