Hotz
Fakultäten » Mathematisch-naturwissenschaftliche Fakultät » Evolutionsbiologie und Umweltwissenschaften, Institut für » Ecology & Environment » Dr. Hansjürg Hotz (ausgetreten) » Hotz
Completed research project
| Title / Titel | Gene mapping and genetic basis of clonal reproduction on water frogs | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | Interspecies hybrids of European water frogs transmit the chromosomes of only one parental species to gametes and thus to progeny; the other parental genome is lost in the germ line of both sexes. As part of an analysis of the genetic basis of such reproduction without recombination, we have determined linkage groups among protein-coding loci and sex using backcross progeny of selected non-clonal species hybrids. Results include: (1) Several syntenies of protein-coding genes are shared with other frog groups and even with mammals and with fish and therefore are evolutionarily highly conserved, having persisted for up to 400 million years. (2) In contrast, chromosomal localization of the major sex-determing locus or region is highly variable and differs among closely related frog species and even among populations of a species. (3) Males showed markedly reduced intrachromosomal recombination rates relative to females for large, but not for small chromosomes. (4) We have detected both intra- and interspecies variation in genetic traits connected to clonal gametogenesis of hybrids. Such variation can be used for the analysis of the genetic basis of clonal reproduction. |
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| Publications / Publikationen | Bucci, S.; Ragghianti, M.; Mancino, G.; Berger, L.; Hotz, H. & Uzzell, T. (1990): Lampbrush and mitotic chromosomes of the hemiclonally reproducing hybrid Rana esculenta and its parental species. J. Exp. Zool. 255: 37-56.Guerrini, F.; Bucci, S.; Ragghianti, M.; Mancino, G.; Hotz, H.; Uzzell, T. & Berger, L. (1997): Genomes of two water frog species resist germ line exclusion in interspecies hybrids. J. Exp. Zool. 279: 163-176.Hotz, H.; Uzzell, T. & Berger, L. (1997): Linkage groups of protein-coding genes in western Palearctic water frogs reveal extensive evolutionary conservation. Genetics 147: 255-270. | ||||||||
| Keywords / Suchbegriffe | amphibian, crossover frequency, genetic map, germ line, hybridogenesis, lampbrush chromosomes, linkage, linkage group evolution, meiotic drive, protein electrophoresis, Rana esculenta group, recombination rate, sex chromosomes, sex determination, sex reversal, sex-specific recombination frequency, synteny | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | to Dec 2005 |