Curt Schwab
Fakultäten » Medizinische Fakultät » Universitätsklinik Balgrist und Schweizerisches Paraplegikerzentrum » Paraplegikerzentrum » Prof. Dr. Armin Curt » Curt Schwab
Completed research project
| Title / Titel | Spinal Cord Repair | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | This project combines basic and clinical research with the following objectives: - To develop treatments for the regeneration of nerve fibers in the spinal cord from preliminary experimental stages up to clinical application. - To enhance the adaptability (plasticity) of the spinal cord and the brain by means of specific training or by growth-promoting factors in order to achieve maximum recovery of lost functions. Experimental studies into defined spinal-cord damage will examine the effect of antibodies, which promote the growth of nerve fibers, by means of behavioral tests, electrophysiological measurements and anatomical studies. Later clinical studies will then draw on this basic research. Antibodies against a human growth-inhibiting protein (Nogo-A) are being developed for this purpose in cooperation with the pharmaceutical industry and tested for their action in cell cultures, rat experiments and on monkeys. Specific physiological, neuroradiological and neurological tests are being developed at the Paraplegia Center Balgrist of the Zurich University Clinic in order to obtain objective data on the process of recovery after damage to the spinal cord and on the effectiveness of new forms of treatment. |
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| Publications / Publikationen | Dietz V, Müller R, Colombo G (2002) Locomotor activity in spinal man: Significance of afferent input from joint and load receptors. Brain 125: 2626-2634.Dietz V, Müller R (2004). Degradation of neuronal function following a spinal cord injury: Mechanisms and countermeasures. Brain 127: 2221-2231.Müller R, Dietz V. Neuronal function in chronic spinal cord injury: Divergence between locomotor and flexion- and H-reflex activity. Clin Neurophysiol 2006;117:1499-1507. | ||||
| Keywords / Suchbegriffe | Spinal Cord Injury, Spinal Locomotion, Locomotor Training, Afferent Input, Load Receptor Function | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Programm NFS/NCCR) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jun 2001 to May 2011 |