Fischer
Fakultäten » Medizinische Fakultät » Universitätsklinik Balgrist und Schweizerisches Paraplegikerzentrum » Orthopädie » Prof. Dr. Jan Fischer (ausgetreten) » Fischer
Completed research project
| Title / Titel | Parathyroid hormone/parathyroid hormone related protein (PTH/PTHrP) receptor signaling and cell differentiation. | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | PTH and PTHrP interact with a G protein-coupled receptor linked to the activation of adenylyl cyclase and phospholipase C signaling pathways. The regulation of target genes by PTH is mediated in osteoblasts predominantly by the activation of the protein kinase A signaling pathway. To this end, distinct, stably transfected luciferase reporter genes responsive to cyclic AMP, serum and phorbol ester have been examined. PTH induced cyclic AMP evoked transcription, and reduced serum, epidermal growth factor and phorbol ester evoked induction also through the protein kinase A pathway. As a result, activation of mitogen-activated protein kinase was inhibited by PTH. Differentiation of neuronal from embryonic cells brought about with retinoic acid was accompanied by the induction of a PTH/PTHrP and repression of a calcitonin receptor. |
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| Publications / Publikationen | Flühmann B, Zimmermann U, Muff R, Bilbe G, Fischer JA, Born W. Parathyroid hormone responses of cyclic AMP-, serum- and phorbol ester-responsive reporter genes in osteoblast-like UMR-106 cells. Mol. Cell. Endocrinol. 1998;139:89-98 | ||||||
| Keywords / Suchbegriffe | Adenylyl Cyclase, Bone, Parathyroid Hormone, Receptor, Reporter Gene | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Universität Zürich (position pursuing an academic career), SNF (Personen- und Projektförderung), Others |
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| Duration of Project / Projektdauer | Jan 1990 to Dec 2004 |