Discrimination between fast- and slow-bone-loser patients and the consequences for the prophylaxis and treatment of osteoporsis.

Completed Research Project

Title / Titel: Discrimination between fast- and slow-bone-loser patients and the consequences for the prophylaxis and treatment of osteoporsis.

Original title / Originaltitel: Unterscheidung zwischen "fast- and slow-loser"-Patienten und die Konsequenzen für die Prophylaxe und Behandlung der Osteoporose.

Summary / Zusammenfassung: We do not anymore discriminate between typ I and typ II osteoporosis but between "slow- and fast bone loser" patients. A fast bone loser is defined as a patient who loses more than 3 % trabecular bone density/year.
We could demonstrate that in contrast to the current opinion in Switzerland, Germany and also in Hong Kong in a Chinese population the perimenopausal bone loss is 34 % resp. 33 %. In contrast to this in severe osteoporosis with very low bone density 75 % of the patients show a "fast bone loss". This is also in contrast to the current opinion. We treat "fast bone loser" patients with antisorptive substances (estrogens, bisphosphonates, active vitamin D metabolites, calcitonin) and "slow bone loser" with anabolic substances (e.g. fluorides). We could show that this concept is correct using bisphosphonates and calcitonin.

Publications / Publikationen: Dambacher MA, Neff M, Kissling R, Qin L. Highly precise peripheral quantitative computed tomography for the evalutation of bone density, loss of bone density and structures. Drugs & Aging 1998;12 Suppl. 1:15-24

Keywords / Suchbegriffe: fast- and slow-bone-loser patients, treatment of osteoporosis, highly precise quantitative computed tomography

Project Leadership and Contacts / Projektleitung und Kontakte

Prof. Dr. L. Qin	lingqin@cuhk.cdu.hk
Prof. Dr. M.A. Dambacher (Project Leader)

Funding Source(s) / Unterstützt durch: Others
Osteoporosezentrum Dr. M. Neff, Zürich
Osteoporosezentrum Dr. H. Radspieler, München
Chinese University of Hong Kong, Prof. Dr. L. Qin