Dambacher
Fakultäten » Medizinische Fakultät » Universitätsklinik Balgrist und Schweizerisches Paraplegikerzentrum » Orthopädie » Prof. Dr. Christian Gerber » Dambacher
Completed research project
| Title / Titel | Discrimination between fast- and slow-bone-loser patients and the consequences for the prophylaxis and treatment of osteoporsis. | ||||
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| Abstract (PDF, 14 KB) | |||||
| Original title / Originaltitel | Unterscheidung zwischen "fast- and slow-loser"-Patienten und die Konsequenzen für die Prophylaxe und Behandlung der Osteoporose. | ||||
| Summary / Zusammenfassung | We do not anymore discriminate between typ I and typ II osteoporosis but between "slow- and fast bone loser" patients. A fast bone loser is defined as a patient who loses more than 3 % trabecular bone density/year. We could demonstrate that in contrast to the current opinion in Switzerland, Germany and also in Hong Kong in a Chinese population the perimenopausal bone loss is 34 % resp. 33 %. In contrast to this in severe osteoporosis with very low bone density 75 % of the patients show a "fast bone loss". This is also in contrast to the current opinion. We treat "fast bone loser" patients with antisorptive substances (estrogens, bisphosphonates, active vitamin D metabolites, calcitonin) and "slow bone loser" with anabolic substances (e.g. fluorides). We could show that this concept is correct using bisphosphonates and calcitonin. |
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| Publications / Publikationen | Dambacher MA, Neff M, Kissling R, Qin L. Highly precise peripheral quantitative computed tomography for the evalutation of bone density, loss of bone density and structures. Drugs & Aging 1998;12 Suppl. 1:15-24 | ||||
| Keywords / Suchbegriffe | fast- and slow-bone-loser patients, treatment of osteoporosis, highly precise quantitative computed tomography | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Others Osteoporosezentrum Dr. M. Neff, Zürich Osteoporosezentrum Dr. H. Radspieler, München Chinese University of Hong Kong, Prof. Dr. L. Qin |
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| Duration of Project / Projektdauer | Jan 1998 to Dec 2003 |